En tant que spécialiste, vous déterminez la consistance et les besoins du patient en fonction des problèmes de mastication et de déglutition. Il est donc important que votre thérapie et vos recommandations soient correctement suivies.

Recommandez-vous l’un des produits ThickenUP_® de Nestlé Health Science ? Utilisez ensuite le document à remplir avec les produits disponibles sur le marché. De cette façon, en tant que spécialiste, vous pouvez être sûr que le patient peut récupérer le produit que vous recommandez.

Compleat Plant Protein 1.6 est un aliment en tube complet, avec des protéines de haute qualité, qui convient comme aliment complet.

Nous pouvons annoncer la disponibilité de Compleat® Plant Protein 1.6. Un aliment en tube entièrement végétal, riche en énergie et en protéines, qui s'inscrit dans le cadre d'un régime végétalien.

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Liesbeth de Jongh-Kampherbeek, diététicienne pédiatrique à l'hôpital pour enfants Wilhelmina (WKZ/UMC Utrecht), et Carlijn van Ophuizen, diététicienne pédiatrique à l'hôpital Jeroen Bosch, sont toutes deux expertes dans le domaine du "blended diet", une méthode qui consiste à préparer des aliments mixés de manière à ce qu'ils puissent être administrés par sonde. Nous nous sommes entretenus avec eux pour en savoir plus sur leur expertise. Lisez l'intégralité de l'interview ici! et apprenez-en plus sur le régime mixé!

PUBLICATION SUMMARY

Effects of an Oral Nutritional Supplementation Plus Physical Exercise Intervention on the Physical Function, Nutritional Status, and Quality of Life in Frail Institutionalized Older Adults: The ACTIVNES Study

Abizanda P, López MD, García VP, Estrella Jde D, da Silva González Á, Vilardell NB, Torres KA* J Am Med Dir Assoc. 2015 May 1;16(5):439.e9-439.e16

Objective

To assess the effects of a high protein high calorie ONS with prebiotic fiber, vitamin D, and calcium (Resource® Senior Activ), plus a standardized physical intervention, in the functional status, strength, nutritional status, and quality of life of frail institutionalized older adults.

Materials and Methods

Population

• 4 nursing homes in Spain : 91 elderly residents
• ≥ 70 years
• Able to walk 50m
• Sarcopenic (or at risk: ≥ 3 Fried failty test)

Intervention

• Nutrition: 2x 200ml Resource® Senior Activ
• Physical exercise: 5x week (balance, flexibility, strength)

Measurements

Results

• 76% completed the 12 week intervention (n=69)
• Adherence to ONS: 62.6% of participants consumed >80%
• Adherence to exercise: 93.4% of participants exercised >80%

Function Status

• Mean values significant after 6 weeks but not 12 weeks

Quality of Life

• EQ-5D VAS – 6 weeks: 60–66 (6; 3–10)†
• EQ-5D VAS – 12 weeks: 59–64 (5; 0–10)∗

Nutrition Status

• Weight 59.9–61.6 (1.7; 0.9–2.5) ‡
• BMI: 26.5–27.3 (0.8; 0.4–1.2)‡
• MNA: 10.3–11.1 (0.8; 0.1–1.5)∗
• Speed ​​D: 17.4–25.3 (7.9; 5.0–10.8)‡

∗ P < .05 ; † P < .01 ; ‡ P < .001. Participants had greater probability of improving functional status when they presented with lower baseline scores, lower baseline BMI, lower vitamin D levels, and more baseline frailty criteria.

Conclusion

• A specific ONS supplementation (high protein, high calorie, extra vit D and calcium) plus physical exercise in frail institutionalized older adults, improved functional status at 6 weeks, nutritional status at weeks 6 and 12, and quality of life at weeks 6 and 12.
• Elderly residents with a lower BMI, lower previous physical function, higher number of frailty criteria, and lower vitamin D levels had an independent association with functional improvement.

Full study

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Summary

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Dans cet essai randomisé multicentrique, les nourrissons (≤12 mois) ont reçu soit Althéra^® HMO (n=97) soit Althéra^® (n=97) jusqu'à ce qu'ils atteignent l'âge de 12 mois.

Principaux résultats: L'ajout d'oligosaccharides de lait humain (HMO) 2'FL et LNnT a semblé corriger la dysbiose intestinale du microbiome causée par l’APLV. On a constaté une augmentation des bifidobactéries de type infantile et une diminution des bactéries nocives, y compris des protéobactéries.

_{^{Reference: Boulangé CL, Pedersen HK, Martin FP, Siegwald L, Pallejà Caro A, Eklund AC, Jia W, Zhang H, Berger B, Sprenger N, Heine RG, Cinnamon Study Investigator Group. An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow's Milk Protein Allergy. Int J Mol Sci. 2023 Jul 13;24(14):11422. doi: 10.3390/ijms241411422.}}

Vous voulez en savoir plus ? Consultez l'infographie ci-dessous pour un bref résumé.

CINNAMON STUDY: AN EXTENSIVELY HYDROLYZED FORMULA SUPPLEMENTED WITH TWO HUMAN MILK OLIGOSACCHARIDES MODIFIES THE FECAL MICROBIOME AND METABOLOME IN INFANTS WITH COW’S MILK PROTEIN ALLERGY

Boulangé CL et al. Int J Mol Sci. 2023 Jul 13;24(14):11422.

Study objectives

To evaluate the effects of Althéra^® HMO, an extensively hydrolyzed formula (EHF) supplemented with two human milk oligosaccharides (HMO:2’-Fucosyllactose [2’- FL] and Lacto-N-neotetraose [LNnT]) on the fecal microbial ecosystem in infants with CMPA. This was part of the original CINNAMON (Vandenplas 2022) was to assess growth and the effects of HMOs on infection rates.

Subjects and methods

Multicenter, randomized, controlled, double-blind clinical trial, comparing two parallel infant groups.

• Infants aged 0–6 months with CMPA were randomized to receive a lactose-containingEHF, with1.0 g/L of 2′-FL& 0.5 g/L of LNnT( Althéra^® HMO)orwithoutHMO (control, Althéra^®)
• Stool samples were collected at baseline (Visit 0), 1 month (Visit 1), 3 months (Visit 3), and 12 months (Visit 6).
• Infants were stratified into early (0-3 months) and late (3-6 months) enrollment groups to reduce the confounding effects of age and complementary diet.

Endpoints

• Microbiome composition and fecal metabolomic signature were analyzed using shotgun metagenomics and targeted mass spectrometry.
• The development of the infant’s microbiome was monitored over time by tracking 5 fecal community types (FCT) - samples with similar microbiome composition.

Results

Feeding with an HMO-supplemented hypoallergenic formula containing 2ʹ-FL and LNnT in infants with CMPA partially corrected the intestinal microbial dysbiosis by enriching infant-type bifidobacteria, and reducing the abundances of other harmful bacteria such as proteobacteria.

Supplementation with 2’-FL and LNnT delayed the transition of the microbiome composition towards an adultlike pattern (FCT5), which may prolong the window period for early immune modulation.

There was an early increase in acetate production in the HMO group, whereas in the control group, acetate decreased.

There was a major shift in microbiome composition and metabolome profile at around 6 months of age, due to the effects of complementary diet and increased bacterial fermentation of dietary fibre.

• HMOs shape the microbiome composition for this transition and promote healthy early immune development.

Conclusion

• 2ʹ-FL and LNnT supplemented in hypoallergenic formula partially corrected the intestinal microbial dysbiosis.
• 2ʹ-FL and LNnT contributed to a healthier, age-appropriate gut microbiome and promoted immune-modulatory effects, including a lower rate of respiratory tract infections and otitis media.